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KMID : 0360319940260050756
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 5 p.756 ~ p.763
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Quantitation of AgNORs in Breast Lesions Using Image Analysis
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Abstract
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The argyrophilic nucleolar organizer regions(AgNORs)staining is one of the useful methods for the estimation of proliferative activity in conventional histologic sections in various benign and malignant lesions. Because of difficulties in AgNORs
counting, there is a relucance to accept the technique as a reliable diagnostic tool.
We measured the area and numbers of AgNORs in 22 surgically resected infiltrating ductal carcinomas and 5 fibroadenomas using image analyzer and also visually enumerated the numbers at (1000magnification. The number of AgNORs by visual conuting
was
correlated with the area measured by Image counting(r-0.56). The mean area of AgNORs in the malignant group(4.36μ㎡) was significantly different(p<0.0001) from that of the benign group(0.79μ㎡). As the number of AgNORs increased, the area
increased(r=0.709).
The result of this study suggests that measurement using image analyzer can give more objective and reproduccible measurement of AgNORs than visual counting.
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KEYWORD
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